Thank you for your interest in RADIESSE® wrinkle filler, the FDA–approved injectable implant that is aiming to become the new standard for the correction of moderate to severe facial wrinkles and folds such as nasolabial folds. RADIESSE filler has long been used for vocal fold augmentation, maxillofacial augmentation, and radiographic tissue marking, and has become a premier dermal filler for aesthetic uses.

The benefit of a RADIESSE® wrinkle filler treatment is unique because it utilizes a calcium–based microsphere technology and stimulates the body to produce new collagen to instantly smooth out the signs of aging. RADIESSE cosmetic filler is safe and long lasting, giving your patients the convenience and longevity they desire.

RADIESSE® wrinkle filler consists of smooth calcium hydroxylapatite (CaHA) microspheres that are suspended in a water-based gel carrier. Over time, as the patient's own soft tissue replaces the gel carrier, the newly formed collagen provides the desired long–term effect. These unique advantages make RADIESSE® filler treatments the ideal choice to fill moderate to severe wrinkles and folds such as nasolabial folds or marionette lines.This immediate and long lasting correction of facial wrinkles makes RADIESSE® wrinkle filler the natural choice for your practice and your patients.

Restylan® Fequently Asked Questions

RADIESSE® Wrinkle Filler — "The Difference"

Compared with other injectable fillers, RADIESSE® wrinkle filler offers significant advantages.


  • Associated with allergic reactions
  • Sensitivity testing is required for most brands
  • Effects only last an average of three to six months, regardless of the type used

Hyaluronic Acid

  • Over–correction required in many areas
  • Effects may last up to a year, depending on the brand

Poly–L–lactic Acid

  • Requires three to six applications spaced weeks apart
  • Effects are not seen until months after the initial treatment

RADIESSE® Dermal Filler

  • Delivers immediate correction
  • Typically requires only one treatment for optimal results for most patients (a touch–up may be required)
  • Stimulates the body to produce new collagen over time
  • Results last up to a year or more for many patients
  • Reduces the need for re–treatment
  • More cost–effective for many patients
  • Soft, natural–looking results that feel like the patient's own tissue
  • Primary component is identical in composition to the mineral portion of bones and teeth
  • Contains no human—or animal–derived components
  • Virtually no risk of allergic reaction
  • Does not require sensitivity testing prior to treatment

RADIESSE® Wrinkle Filler — "See The Difference"

Diagram: Radiesse Dermal Fillers Da Vinci Aesthetics Med Spa Houston

RADIESSE® Wrinkle Filler — "Mechanism of Action"

RADIESSE® wrinkle filler is an injectable implant composed of synthetically produced smooth calcium hydroxylapatite (CaHA) microspheres (diameter of 25µm to 45µm) suspended in a sodium carboxymethylcellulose gel carrier. RADIESSE® wrinkle filler is approximately 30% CaHA and 70% gel carrier by volume.

RADIESSE® wrinkle filler is injected into the skin in a minimally invasive procedure. Injection of the product provides an immediate one–to–one correction of the face wrinkle. The amount of filling or augmentation can be easily placed and controlled for better results. There is no skin sensitivity testing or reconstitution required.

Over time, the gel is absorbed, and fibroblasts appear. The process of neocollagenesis begins, stimulating the gradual growth of the patient's own collagen. The collagen that forms results in extended correction times and increased patient satisfaction.

The cosmetic results are soft and natural–looking, and feel like the patient's own tissue. The results are long–lasting, but not permanent. The CaHA microspheres naturally degrade to calcium and phosphate ions, which are metabolized by the body's normal processes.

RADIESSE® Wrinkle Filler — "How It Works"

Diagram: Radiesse Dermal Filliers Da Vinci Aesthetics Med Spa Houston Upon injection, RADIESSE® wrinkle filler immediately adds volume to facial features.
Diagram: Radiesse Dermal Filliers Da Vinci Aesthetics Med Spa Houston After two to three months, macrophages start to dissolve the sodium carboxymethylcellulose gel carrier. The CaHA microspheres remain.
Diagram: Radiesse Dermal Fillers Da Vinci Aesthetics Med Spa Houston Macrophages continue to dissolve the gel carrier. Fibroblasts form new collagen.
Diagram: Radiesse Dermal Fillers Da Vinci Aesthetics Med Spa Houston New resident tissue (collagen) surrounds the CaHA microspheres.
Diagram: Radiesse Dermal Fillers Da Vinci Aesthetics Med Spa Houston The CaHA microspheres degrade and are phagocytized and metabolized by macrophages.
Diagram: Radiesse Dermal Fillers Da Vinci Aesthetics Med Spa Houston Even the small fragments of CaHA are decomposed at the implant site, without evidence of migration.

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